NIH R01 · 2024
Omni Oblique Plane Microscope to spread light-sheet based imaging in biomedical research
Project Abstract Light-sheet fluorescence microscopy (LSFM), through its gentle, efficient, and fast 3D imaging capacity, has tremendous potential in biological, biomedical, and translational applications. However, LSFM has fragmented into a myriad of specialized instruments, each optimized for a specific class of samples and imaging regimes. As such, the widespread use and ultimate impact of LSFM has been curtailed by its lack of adaptability. Here we propose a universal LSFM platform that can be adapted to a wide range of applications, ranging from sensitive live cell imaging to imaging organs and tissues that have been rendered transparent by different clearing techniques. Further, we…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.