NIH R01 · 2024
Intervention Strategies for Non-Folate Responsive Neural Tube Defects
ABSTRACT Congenital defects are the leading cause of neonatal mortality, resulting in more infant deaths than the combined adult death tolls of Alzheimer’s disease, strokes, diabetes, and influenza. Neural tube defects (NTDs), the second most common category of human birth defects, arise when the neural tube fails to close properly during neurulation. Globally, these defects are estimated to affect approximately 18.6 per 10,000 live births and the prevalence of NTDs is 1–2 per 1,000 births in most regions of the US. There are approximately 2,300 NTD- affected pregnancies in the US each year, whose lifetime medical costs are estimated to be $560,000 per child or $1.68 billion per year…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.