NIH R01 · 2025
Dissecting the Etiology of The Lewy Body Dementias
PROJECT SUMMARY Lewy Body dementia (LBD) is the second most common neurodegenerative disorder, afflicting 1 million people in the US. It is fatal, and its incidence is increasing as populations age. LBD includes dementia with Lewy bodies (DLB) and Parkinson disease (PD) with dementia (PDD), but it is not clear if DLB and PDD are distinct diseases with different underlying mechanisms or clinical syndromes on a single mechanistic spectrum. Their relationship to Alzheimer’s disease (AD) is also unclear. Answering these questions is important for patient care, as DLB patients may respond differently to drugs than PDD or PD patients, and the diseases may progress at different rates. We propose…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.