Finkbeiner Lab

J. David Gladstone Institutes

San Francisco · United States

NIH-funded
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NIH R01 · 2025

Image Tools for Computational Cellular Barcoding and Automated Annotation

PROJECT SUMMARY With technological breakthroughs in high-throughput single-cell imaging and screening, we can precisely monitor native cell behavior in response to diverse stimuli. Improvements in resolution and new detection capacity further enrich the recording from each cell. Many image-processing steps that help to extract the full breadth of the recording can be automated to a throughput comparable to the imaging itself. However, because biological samples can be complex and nonhomogeneous, it is valuable to specify subsets of cells when addressing downstream biological questions. With the amount of data that can now be generated from high-throughput measurements, this subset-selection…

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