NIH R01 · 2024
Unexpected role for AMPK and mTORC1 in cellular adaptation to nutrient stress
Project Summary Signaling networks centered on the conserved protein kinases AMPK (AMP-activated protein kinase) and mTOR (mechanistic target of rapamycin) enable cells to sense and respond appropriately to dynamic fluctuations in a variety of systemic and local cues. Energetic stress activates AMPK to promote catabolic and suppress anabolic pathways to balance energy supply and demand. AMPK also promotes glucose and lipid homeostasis. In fact, the AMPK-activating drug metformin (aka, GlucoPhage) represents the most widely prescribed treatment for type II diabetes. Curiously, AMPK paradoxically functions as a tumor suppressor or tumor promoter depending on cellular context. Nutrients (i.e.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.