NIH R01 · 2025
STK25 phosphorylates PRKAR1A to regulate PKA signaling
Project Summary The development of new therapies in heart failure is a critical need and current drug development in this field is not sufficient to keep pace with the increasing incidence and mortality of this disease. Novel therapeutic targets are required as are model systems that more closely resemble human cardiac physiology. Protein kinase A (PKA) is a cAMP sensitive kinase that is the central relay for beta-adrenergic stimulation of cardiomyocyte contraction and calcium flux. With a broad set of substrates, specificity of signaling relies on careful regulation of both cAMP metabolism and kinase activity. Regulatory subunits of PKA both inhibit kinase activity and help recruit…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.