Chow Lab

University of Virginia

ANESTHESIOLOGY

Charlottesville · United States

NIH-funded
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NIH R01 · 2025

An Adaptive Intervention to Improve Pain Outcomes Following Cognitive Behavioral Therapy for Insomnia in Patients with Comorbid Chronic Low Back Pain and Insomnia

Chronic low back pain (CLPB) affects over a half billion people worldwide and is the leading cause of disability. Sleep disturbance prospectively predicts increased pain, which has led to enthusiasm over the potential for cognitive behavioral therapy for insomnia (CBTi)—the gold standard insomnia treatment—to improve both sleep and pain outcomes in patients with comorbid chronic pain and insomnia. However, the majority of patients do not experience a clinically meaningful pain response (defined as at least 30% reduction in pain) following CBTi. Factors predicting who will or will not be a pain responder to CBTi are poorly understood, limiting the ability to appropriately plan treatments in…

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