NIH R01 · 2024
Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle
PROJECT SUMMARY/ABSTRACT Alcohol use poses significant health problems particularly when characterized by bouts of heavy consumption (i.e., binges). It is now recognized that women demonstrate greater vulnerability to the adverse effects of alcohol, including greater physiological risk of organ damage (e.g., liver cirrhosis), than do men with comparable histories of alcohol use. Research suggests that ovarian hormones play a role in substance abuse. With regard to alcohol use, there is evidence to suggest that women may exhibit distinct patterns of heavy drinking across the menstrual cycle. Indeed, our preliminary research shows that surges in follicular estradiol [E2] at ovulation predict…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.