NIH R01 · 2025
Pericyte-Macrophage Interactions Maintain CNS Immune Tolerance
Pericyte-Macrophage Interactions Maintain CNS Immune Tolerance ABSTRACT Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) where infiltrating T cells ultimately lead to the destruction of myelin. T cells initially accumulate in the perivascular space of the brain and the meninges where they must interact with antigen presenting cells prior to activating and infiltrating into the parenchyma. This suggests immune interactions in the perivascular space may serve as a checkpoint and determine the fate of infiltrating T cells. Macrophages and pericytes are two important cells in the perivascular space of the brain and meninges. Under homeostatic conditions,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.