NIH R01 · 2025
Molecular Antecedents of Miscarriage
Miscarriage - defined as pregnancy loss prior to 20 weeks of gestation - is the most common pregnancy complication, affecting 10-20% of clinically recognized pregnancies. While advances have been made in noninvasive prenatal diagnosis of chromosomal abnormalities leading to pregnancy loss, the pathophysiology and environmental causes of chromosomally normal losses – the bulk of miscarriages occurring after the 6th gestation week – remain largely unexplained. We hypothesize that microRNAs serve as a physiologic “glue” for common pathways predicting loss of chromosomally normal pregnancies. MicroRNAs are non-coding RNAs that negatively regulate gene expression by inducing translational…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.