NIH R01 · 2025
ATP1B3: novel regulator of T cell-mediated immunity
Project Summary T cells are key components of immune responses to infection and in autoimmunity. Like all cells, they require ion channels and transporters for their function. Channels move ions such as calcium, sodium and potassium across lipid membranes to maintain ion gradients, facilitate signal transduction and influence many cellular processes. Several channels are known to play critical roles in immune cells. In general, however, only a small number of the known hundreds of channels have been studied in T cells. This is a major gap in our understanding of T cell biology and the mechanisms underlying T cell-mediated immune responses. From a clinical perspective, ion channels are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.