NIH R01 · 2025
Mevalonate Pathway Regulation of Astrocyte ApoE
Abstract The ApoE 4 isoform is the strongest genetic link to Alzheimer’s disease for unclear reasons. ApoE is a lipid carrying protein. Both the content of the ApoE particles and their release from astrocytes varies by ApoE isoform. We have found that the mevalonate pathway can regulate both the release of ApoE from astrocytes and the lipid content of those ApoE particles. Depending on the part of the pathway that we inhibit we can separate these two functions. We hypothesize that targeting individual components of the mevalonate pathway can be used to manipulate the secretion and composition of ApoE in order to reduce Aβ synthesis and improve neuron survival. Further, we will explore if…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.