NIH R01 · 2024
Reactive Oxygen Species and Respiratory Muscle Dysfunction in Heart Failure
Abstract Diaphragm weakness is a significant health problem in patients with chronic heart failure and reduced ejection fraction (CHF) because it compromises ventilation and airway clearance and contributes to cardiac arrhythmias, peripheral vasoconstriction, and limb muscle fatigue. A mismatch in production and scavenging of reactive oxygen species (ROS), accompanied by oxidative modifications of myofibrillar proteins, is a critical determinant of loss of specific force (i.e., contractile dysfunction) in CHF. In this proposal, our goal is to identify the mechanisms which are causative in diaphragm redox imbalance and ROS-mediated contractile dysfunction in CHF. Based on our data collected…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.