Ferrari Lab

Columbia University Health Sciences

SURGERY

New York · United States

NIH-funded
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NIH R01 · 2024

Revision to Mechanisms of accelerated calcification and structural degeneration of implantable biomaterials in pediatric cardiac surgery

Summary We are proposing a competitive revision for R01 HL163085, that will address in vitro and ex vivo the contribution of systemic vs pulmonary circulation conditions on the mechanisms of structural degeneration of implanted biomaterials for left and right side cardiac reconstruction approaches. Congenital heart defects (CHDs) affect nearly 1% of?or about 40,000?births per year in the United States. More than 40% of CHD patients require the replacement of one of the valves. Congenital lesions of any of the heart valves are associated with a wide spectrum of cardiac malformations, impacting both the left and right side of the heart. Left-side anomalies may involve any component of the…

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