NIH R01 · 2024
Project Summary The brain undergoes anatomical and physiological changes with the onset of puberty, of which synaptic pruning and increased myelination in a posterior-to-anterior gradient are hallmarks. These neural changes are reflected in the sleep electroencephalogram (EEG), with sleep intensity and depth sharply declining and sleep integrity plateauing during adolescence. Supported by R01 MH118308, we leveraged sleep EEG data from a population- based cohort of children followed-up as adolescents with which we studied the age-related trajectories of slow wave activity (SWA), sleep spindle density (SSD) and odds ratio product (ORP), three EEG biomarkers of sleep intensity, integrity and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.