NIH R01 · 2024
PROJECT SUMMARY Alterations in the control of lipid homeostasis can lead to cardiometabolic diseases, including atherosclerosis, the most common cause of mortality in Western societies. Our previous studies have demonstrated the importance of miRNAs in regulating high-density lipoprotein (HDL)-C and LDL-C. Work from our group and others identified miR-33a/b as key regulators of cellular cholesterol efflux and uptake, HDL biogenesis and fatty acid metabolism. Notably, we have recently discovered that miR-33 and the nuclear receptor liver X receptor (LXR) regulates the expression of transmembrane protein 86a (TMEM86a), which is a lysoplasmalogenase that regulates plasmalogen (phospholipid)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.