NIH R01 · 2025
Project Summary Co-use of opioids (fentanyl, heroin) and methamphetamine is now highly prevalent across the U.S., and is associated with severe health risks, including HIV infection and overdose, and poorer treatment outcomes. Yet, the neural circuit alterations and accompanying behavioral changes associated with this polysubstance use are poorly defined, as are the similarities/differences between distinct patterns of opioid/methamphetamine co-use. Notably, the patterning of drug use can have enormous impacts on both circuit-wide brain adaptations and the development of addiction behaviors. Accordingly, delineating whether the outcomes that occur following distinct patterns of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.