NIH R01 · 2025
Moving and shaping neuronal lysosomes in Alzheimer's Disease
Abstract This project will define mechanisms that coordinate late endosome and lysosome functions across the extreme size and polarity of neurons. Although multiple proteins have been implicated in this process, there is a significant lack of understanding concerning how the network of proteins that control of lysosome function is integrated in support of the unique demands of neurons. This is a bottleneck to understanding the mechanisms whereby variants in genes encoding lysosome proteins contribute to multiple neurodegenerative diseases. In particular, this is a barrier to understanding the relevance of abnormal lysosome accumulations that occur within neurons that contact amyloid plaques…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.