NIH R01 · 2025
Regulation of phase separation in neuronal heterochromatin
ABSTRACT One of the most astonishing feats in all of biology is the process by which chromatin, the complex of DNA, histone proteins and associated factors, becomes compacted from a length of 2 m into nuclei that measure just microns across. Unsurprisingly, our understanding of the principles that govern this process is in its infancy. My lab became interested in this process after we identified the Ferguson-Bonni ANAPC7 neurodevelopmental syndrome caused by mutation of the degradative ubiquitin ligase Anaphase-Promoting Complex (APC). We discovered that Ki-67 was the major APC7-dependent target in post-mitotic neurons, where it accumulated in constitutive heterochromatin. Subsequent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.