NIH R01 · 2024
Impact of Menopause on the Aqueous Outflow Pathway
Project Summary/Abstract Glaucoma is the leading cause of irreversible blindness and is projected to affect 112 million people worldwide by 2040. Women represent 59% of the glaucoma population, highlighting the need to understand if there are sex-specific risk factors for glaucoma. For example, early menopause increases the risk of developing glaucoma. Estrogen receptor polymorphisms in women are associated with ocular hypertension (an important causal risk factor for glaucoma). Moreover, menopause causes a 1-3 mmHg increase in intraocular pressure (IOP), while hormone therapy containing estrogen reduces IOP. These data suggest that the age of menopause, menopause and estrogen levels…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.