Fenton Lab

University of California at Davis

EMERGENCY MEDICINE

Davis · United States

NIH-funded
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NIH R01 · 2024

RFA-CE-22-011: Patterns and trajectories associated with overdose in patients co-prescribed opioids and benzodiazepines

PROJECT SUMMARY Despite prevention efforts and reduced opioid prescribing, U.S. overdose rates continue to rise. Millions of patients prescribed opioids for chronic pain are co-prescribed benzodiazepines, which heighten overdose risk. However, tapering either opioids or benzodiazepines may also increase overdose and mental health risks, and clinicians lack evidence-based guidance about how to safely reduce risk in patients who are co- prescribed opioids with benzodiazepines. Rates of fatal and non-fatal overdose involving prescribed opioids or benzodiazepines combined with illicit opioids or psychostimulants are also rapidly increasing. The specific aims of this proposed study are: Aim 1)…

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