NIH R01 · 2024
Role of antibodies in hepatitis E virus infection
Summary The goal of the proposed study is to better understand the role of antibodies in HEV infection and determine if antibodies can prevent or cure chronic hepatitis E virus (HEV) infection. HEV infections are usually self-limited, but the infections frequently persist when the immune system is compromised and if left untreated, can lead to serious liver disease. HEV exists in two distinct virion forms: naked virions (nHEV) that are shed into feces and mediate virus transmission between hosts, and quasi-enveloped HEV (eHEV) virions that circulate in the bloodstream and mediate virus spread between cells. The eHEV particles lack viral antigens on their surface, thus they are resistant to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.