NIH R01 · 2025
CaMKII and Endothelial SK Channel Function in Diabetic Coronary Microcirculation
Summary/Abstract Patients with diabetes mellitus (DM) manifest coronary microvascular endothelial dysfunction, characterized by impaired endothelium-dependent relaxation. Impaired endothelium-dependent vasodilation decreases coronary blood flow and myocardial perfusion, resulting in cardiac dysfunction/diabetic cardiomyopathy, and myocardial ischemia with no obstructive arteries (INOCA), which increase morbidity and mortality in the diabetic population. Our recent studies indicate that dysfunction of small-conductance calcium-activated potassium channels (SK channels) play a key role in DM-induced endothelial dysfunction in animal and human coronary microcirculation. However, the mechanisms…
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