NIH R01 · 2025
Mechanisms of lmmunosuppression in MYCN-driven Neuroblastoma
PROJECT SUMMARY Enhanced MYCN activity drives the initiation, progression, and treatment resistance of multiple solid tumors, especially those arising from the brain, the spinal cord, or neural crest. Neuroblastoma, derived from the peripheral sympathetic ganglia, accounts for the second leading cause of deaths among children with solid tumors. Like many other solid tumors, MYCN-driven high-risk neuroblastoma harbors an immunosuppressive tumor microenvironment (TME), characterized by few cytotoxic lymphocytes and poor responses to immunotherapy. Despite intensive efforts, the mechanisms through which MYCN promotes an immunosuppressive TME remain incompletely understood and strategies to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.