NIH R01 · 2024
Novel Role Of ACTN4 in Sodium Reabsorption and Salt-Sensitive Hypertension
PROJECT SUMMARY The Na+/K+/2Cl- co-transporter (NKCC2) is the main sodium transporter in the medullary thick ascending limb (mTAL), and enhanced activity of NKCC2 has been linked to hypertension in animal models and humans. We recently found mutant ACTN4—a cytoskeletal protein previously known to contribute to human podocyte dysfunction and glomerular disease—leads to salt sensitive hypertension in a novel rat model. ACTN4 is expressed in mTAL, and we found in our new adaptation of organ-on-chip technology, mTAL-on-chips, that mutant ACTN4 contributes to increased sodium uptake within mTAL cells via enhancing NKCC2 activity. Our long-term goal is to define the role of ACTN4 in regulating…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.