NIH R01 · 2025
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or meaningful treat- ments. ALS is mostly sporadic, and for most, evidence supports a gene-time-environment hypothesis of ALS triggered by a confluence of nonmodifiable risk factors (age, sex, and genetics) and modifiable risk factors from the exposome (a person’s cumulative lifetime exposures). Exposures imprint on the epigenome via DNA meth- ylation (DNAm) marks, which change with age, modifying cellular response to environmental insults. Compre- hensive knowledge of all these factors is needed to develop personalized prevention strategies for those at highest risk and personalized therapeutics…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.