NIH R01 · 2024
Defining the components of olfactory singular expression
Abstract Monoallelic expression is an unusual form of gene regulation that is often associated with genes that determine cell-type identity. The olfactory system exhibits an intriguing form of random monoallelic expression. Each sensory neuron in the mouse nose expresses only one out of over 2000 odorant receptor (OR) alleles. The current model for OR gene selection involves the interchromosomal aggregation of distributed enhancers into a single active super- enhancer, driven by the co-binding of transcription factors Lhx2 and Ebf. This super-enhancer complex attracts all OR promoters. How this assembly selects a single OR gene promoter for transcription is unknown. Understanding this…
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