NIH R01 · 2024
Potential Role for Sperm miRNAs 34c and 449a in the Transgenerational Effects of Trauma in Men
Project(Summary( ( Exposure to trauma when young, or as and adult, enhances one's risk for a variety of stress-associated disorders, such as anxiety/depression and/or PTSD (A/D or P). These stressors also put one's offspring at risk for a variety of psychological disorders. The majority of this effect is likely due to trauma-associated alterations in the interactions of parents with children, but a growing body of evidence in mice suggests that at least some of this effect may be due to epigenetic inheritance of the effect of trauma, mediated by stress-induced changes in the levels of specific sperm micro-RNAs (miRNAs) that influence zygote development after fertilization. Our recent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.