NIH R01 · 2024
Epigenetic control of developmental gene regulation
PROJECT SUMMARY Although multiple epigenetic processes contribute to developmental gene regulation, the mechanisms by which they rewire gene regulatory networks during lineage specification are often unclear. Defects in epigenetic gene regulation contribute to developmental disorders and disease. Nuclear RNAs, including multiple classes of non-coding RNAs and nascent transcripts of coding genes help regulate the epigenetic landscape and facilitate developmental gene regulation. We have focused on the functions of R-loops—RNA/DNA hybrids that most often arise when nascent transcripts hybridize to their DNA templates—in the control of epigenetic gene regulation in mouse embryonic stem cells…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.