NIH R01 · 2025
PROJECT SUMMARY Organic nitrate esters are long-appreciated treatments for cardiovascular disease (CVD), leading causes of death worldwide. Of note, organic nitrates have never been detected biologically, and their vasodilatory effects are attenuated by the development of nitrate tolerance and endothelial dysfunction, highlighting an urgent need for alternative therapies. In this context, dietary interventions reduce CVD incidence and mortality. While benefits of the dietary interventions are clinically well documented, new data continues to emerge as to the contributions of individual dietary constituents in mediating beneficial downstream responses. Consumption of fruits, vegetables,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.