Fayad Lab

Research focus

NIH R01 · 2025

Advanced multi-parametric 18F-FDG PET and MRI imaging parameters of response to immune suppressant therapy in patients with active cardiac sarcoidosis

PROJECT SUMMARY Sarcoidosis is a systemic condition characterized by non-caseating granulomas affecting ~200,000 Americans. Granuloma infiltration in the myocardium leads to inflammation, fibrogenesis, ventricular arrhythmias, and increased morbidity and mortality. Imaging determinants of cardiac sarcoidosis (CS) include late gadolinium enhancement (LGE) on cardiac MR (CMR) indicating fibrosis, uptake of 18F-FDG on PET indicating inflamma- tion, and perfusion deficits on 82Rb myocardial PET perfusion imaging (MPI) indicating microvascular constric- tion secondary to either fibrosis or inflammation. Each have been identified as predictors of future clinical events. While early…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.