NIH R01 · 2025
Exploring the angiogenesis-to-fibrosis transition in ischemic retinopathies Renewal
Diabetic retinopathy (DR) and other forms of retinal ischemia are a leading cause of blindness in working age adults. There is a need to identify the mechanisms underlying the transition from angiogenesis to fibrosis in these conditions, as a first step towards new therapies to address progressive retinal vascular damage that ultimately leads to pre-retinal fibrosis and traction detachment with poor visual and anatomic outcomes. To address this gap in our knowledge, we have designed a series of experiments that build logically on our preliminary data which shows robust evidence for pericyte involvement in fibrovascular tissues, and the potential markers. We have optimized the timepoints for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.