NIH R01 · 2025
Clinical applications of urine proteomics to lupus nephritis
Abstract Lupus nephritis (LN) is diagnosed by kidney biopsy in patients with proteinuria > 0.5g/24h, but the presence of proteinuria means that kidney damage has already occurred. It is estimated that 30% of nephrons are permanently lost with each flare of LN. The identification of LN before kidney damage using urine proteomic biomarkers could shift the management strategy of LN to prevention, potentially leading to earlier, more effective, and less toxic treatment. Three specific aims will be addressed in this R01 building on the work of the Hopkins Lupus Cohort (a 35 year, 2855 SLE longitudinal cohort in which patients are followed by protocol every 3 months) and in particular on the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.