NIH R01 · 2025
PROJECT SUMMARY Multiple organ dysfunction syndrome (MODS), most commonly caused by sepsis, is a hyperinflammatory condition in which ≥2 organ systems are dysfunctional. Disseminated microvascular thrombosis is a hallmark of MODS. When MODS presents with thrombocytopenia, pediatric mortality is as high as 80%. The combination of inflammation, thrombosis and thrombocytopenia suggests that platelet dysfunction plays a central role in pediatric MODS. Our highly promising preliminary data supports a role for endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in producing a heterogeneous dysfunctional platelet response, including apoptosis. Due to inflammation and other…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.