NIH R01 · 2024
Regulation and role of leptin in preeclampsia
Preeclampsia (PE) is a hypertensive disease in pregnancy that is a leading cause of adverse maternal and fetal outcomes in the US. Decades of clinical studies demonstrate that levels of the adipokine leptin inappropriately increase, independent of body mass, in PE patients. However, whether leptin plays a role in the cardiovascular and fetal outcomes of PE is unknown. We recently established a mouse model of leptin-induced PE, in which exogenous leptin administration induces the clinical characteristics of PE in endothelial dysfunction, hypertension, placental mitochondrial dysfunction and fetal growth restriction when given in mid-late gestation pregnant mice. The goal of this proposal is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.