NIH R01 · 2025
Quantitative assessment of glaucomatous conventional outflow dynamics
PROJECT SUMMARY/ABSTRACT Glaucoma, a leading cause of blindness worldwide, is clinically treated by lowering intraocular pressure (IOP) which can delay or prevent vision loss. However, first-line standard-of-care treatments for primary open-angle glaucoma (POAG), the most common form, do not target the conventional outflow pathway (COP) where IOP is tightly regulated and pathology causes elevated IOP. Moreover, much of our knowledge about COP anatomy was derived from histological samples that are subject to artifacts from long-term glaucoma therapy that alters physiologic outflow. Unfortunately, these samples represent only a snapshot in time and space of the dynamic, spatially…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.