NIH R01 · 2024
Calcium Dynamics in Interstitial Cells of Cajal
PROJECT SUMMARY Interstitial cells of Cajal (ICC) are one of the two known main classes of interstitial cells that regulate gastrointestinal (GI) motor functions in health and disease. Throughout the GI tract, ICC modulate smooth muscle excitability, facilitate efferent and afferent neural control, and generate electrical slow waves (SWs), which drive phasic contractile activity underlying peristalsis and segmentation. Pacemaker activity is compartmentalized in specific ICC classes in an organ-specific manner. Current models of SW generation involve spontaneous transient inward currents triggered by Ca2+ release from the endoplasmic reticulum, activation of other ion channels including…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.