NIH R01 · 2024
Mitochondrial diversity as a regulator of cell- and circuit-specific functions
PROJECT SUMMARY/ABSTRACT The goal of this research proposal is to gain mechanistic insight into how the distinct mitochondrial properties of hippocampal CA2 neurons contribute to their function in learning and memory. Area CA2 is an understudied region of the hippocampus that has recently gained attention due to its unique capacity to encode social infor- mation. However, the molecular mechanisms underlying the essential processes in CA2 required for its function in social memory are unknown. This proposal builds upon our recent finding that hippocampal CA2 pyramidal neurons have molecularly and functionally distinct mitochondria compared with neighboring CA1 neurons. Spe- cifically, our…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.