NIH R01 · 2024
Alzheimer Disease Genetic Architecture in African Americans
ABSTRACT A portion of the genetic component of Alzheimer disease (AD) is explained by genes identified by positional cloning, targeted gene analysis, GWAS and next generation sequencing approaches. With few notable exceptions, the functional variants in these genes and precise pathogenic mechanisms by which these variants lead to AD are unknown. We will continue to direct our efforts on persons of African ancestry (AA), a group with a high incidence of dementia but studied much less than persons of European ancestry (EA). We will leverage rich AD-related endophenotype and other risk factor data from the largest collection of AAs assembled by us, the Alzheimer Disease Genetics Consortium…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.