NIH R01 · 2025
Structural Dynamics in Rhodopsin Activation and Attenuation
Project Summary Understanding of how vision occurs in humans, and how some retinal diseases affect this process, requires a mechanistic and molecular level understanding of the proteins involved. Over the past two decades, significant progress has been made in unraveling the intricate molecular processes involved in human vision, especially in low-light conditions. Detailed insights have been gained into the activation of rhodopsin, the photoreceptor responsible for dim-light vision, including the pathways, factors affecting its chemical reactions, and the stability of its retinal attachment. There has even been considerable success in obtaining structural information about rhodopsin in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.