NIH R01 · 2025
Regulation and Function of RAB7 in the pulmonary endothelium
Pulmonary arterial hypertension (PAH) has a 3-year mortality rate of up to 55%. The survival benefit of vasodilator therapy does not last beyond one year, indicating that pulmonary artery (PA) remodeling, rather than vasoconstriction, predicts long-term prognosis. New anti-proliferative therapies emphasize targeting PA remodeling in PAH. A better understanding is needed of how ECs create an abnormal microenvironment that promotes PA remodeling. This proposal aims to fill this crucial knowledge gap by elucidating a novel mechanism by which ECs profoundly impact other PA mural cells. The discovery that the endosomal GTPase RAB7 is a critical gatekeeper for lung EC and vascular function forms…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.