NIH R01 · 2024
Project Summary/Abstract Alzheimer’s disease (AD) gene-risk data, epidemiological findings and animal models converge to indicate the critical role of inflammation for the onset and progression of AD. Inflammation could provide a new focus for therapeutic intervention. However, inflammation biomarkers are poorly characterized in AD. In this project, we will measure blood and cerebrospinal fluid (CSF) inflammation biomarkers and compare them to measurements of brain glial activation obtained by positron emission tomography (PET). In addition, we will determine the effect of low-dose interleukin-2 (IL-2) immunotherapy, given over 22 weeks, on these inflammation biomarkers. For this purpose,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.