NIH R01 · 2025
An RNA Nanosensor for the Diagnosis of Antibiotic Resistance in M. Tuberculosis
Project Summary: Mycobacterium tuberculosis (Mtb) has among the highest resistance rates of any pathogen globally, but Mtb resistance remains the most challenging to diagnose due to its very slow growth in in vitro culture and culture’s inordinate cost and biohazard. Rapid and accurate alternative diagnostic approaches are urgently needed. DNA based tests are available for detecting resistance to a few drugs but are limited by their need for extensive knowledge of DNA resistance determinants for interpretation, and concerns about limit of detection at the point- of-care. For novel antibiotics entering clinical use, genetic resistance determinants are particularly poorly understood and may…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.