NIH R01 · 2025
Comprehensive Analysis of Oxalate Homeostasis in Calcium Oxalate Kidney Stone Formers
SUMMARY Urinary oxalate excretion is a key risk factor in the formation of calcium oxalate kidney stones, the most common type of kidney stone, a disease that affects 9% of the US population. Therapeutic development for prevention of calcium oxalate kidney stone disease is hampered by our incomplete understanding of the factors leading to the increased urinary oxalate pool in many patients with calcium oxalate kidney stones. Environmental and lifestyle factors as well as dietary and metabolic, or endogenous, factors may all play a role, but the interplay between them has clouded the interpretation of the oxalate focused studies that have been done in kidney stone formers. Our preliminary…
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