NIH R01 · 2024
Lipotoxic Protective Response of the Endoplasmic Reticulum
Lipid homeostasis is crucially important for cells, and disruptions in this balance can lead to diseases of lipid overload, such as obesity-related disorders. Lipid homeostasis is mainly coordinated in the endoplasmic reticulum (ER), the largest membrane system in cells. The ER is a well-recognized location for synthesis of membrane and secreted proteins, processes that are safeguarded by the “unfolded protein response” (UPR). Recent studies suggest that a complementary and interrelated pathway, which we term the “lipotoxic protective response” (LPR), acts in parallel to maintain ER lipid homeostasis. In contrast to the UPR, however, knowledge of the molecular aspects of the LPR remain…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.