NIH R01 · 2025
PROJECT SUMMARY- Triglyceride (TG)-rich ApoB-containing lipoproteins (BLP) are micelle-like particles that enable efficient transport of lipids through the bloodstream, but also promote atherosclerotic cardiovascular disease (CVD), the leading cause of death worldwide. Although the lipid content of BLP is known to be a strong determinant of CVD risk, very little is known about how ER lipids are loaded onto nascent BLP prior to entering the secretory pathway. Whereas invertebrate lipoproteins predominantly transport cholesterol and are quite small, vertebrate lipoproteins evolved the additional capacity to transport TGs in much larger BLP. Neither the mechanistic basis nor the physiological…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.