NIH R01 · 2024
Dual-slope method for enhanced depth sensitivity in frequency-domain near-infrared spectroscopy
PROJECT SUMMARY In this Bioengineering Research project, we propose to develop a novel technique for frequency-domain near- infrared spectroscopy (FD-NIRS) that aims to achieve selective sensitivity to deeper tissue in non-invasive diffuse optical spectroscopy and imaging. A technique that features a stronger sensitivity to deeper tissue relative to superficial tissue can have a broad impact on non-invasive optical diagnostics and monitoring and is especially important in cerebral oximetry and functional brain imaging. The proposed technique is based on the new concept of phase dual-slopes (this is the phase of the modulated optical signal measured in FD-NIRS), which requires a minimum of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.