NIH R01 · 2024
SUMMARY. MarR (Multiple antibiotic resistance Repressor) proteins comprise an ancient family of transcription factors that are widely conserved in bacteria. In the enteric pathogen Salmonella Typhimurium, MarR is a negative regulator of the AcrAB-TolC drug efflux pump, while another MarR transcription factor called SlyA is a counter-silencer required for the expression of horizontally-acquired virulence genes. We have recently shown that despite its divergent function, SlyA shares with MarR the ability to undergo allosteric modulation by aromatic carboxylate molecules and can influence the mar phenotype by repressing the marRAB operon. Inactivation of TolC, an essential component of the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.