NIH R01 · 2024
Mechanisms of Primary Cilia Regulating Tendon Enthesis Development and Regeneration
PROJECT SUMMARY 40% of the population over the age of 60 experiences a rotator cuff tear. The high failure rates of rotator cuff tear after surgical repair or non-surgical treatment make it a major clinical challenge. The outcome failures accompany the formation of scar tissues at the tendon-to-bone insertion (tendon enthesis) with disorganized architecture and deteriorated function. Development of effective therapeutics has been hampered by limited knowledge of enthesis development biology and mechanobiology and an incomplete understanding of endogenous mechanisms governing enthesis pathogenesis and healing. To bridge this knowledge gap, the current proposal seeks to elucidate how tendon…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.