Fan Lab

University of Michigan at Ann Arbor

BIOMEDICAL ENGINEERING

Ann Arbor · United States

NIH-funded
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NIH R01 · 2024

Point-of-care micro-gas chromatography device for diagnosis and monitoring of acute respiratory distress syndrome using exhaled breath signatures

PROJECT SUMMARY / ABSTRACT Acute respiratory distress syndrome (ARDS) is common, costly, and responsible for high mortality and long- term morbidity. Unfortunately, our understanding of patient susceptibility and the underlying pathobiology of ARDS is incomplete, resulting in imprecise ARDS diagnosis and the inability to accurately track its progression. Exhaled breath contains hundreds of volatile organic and inorganic compounds (VOCs and VICs), many of which are related to inflammatory and metabolic processes in the lungs and other organs. The goal of the proposed project is to refine and test a novel, portable micro-gas chromatography (micro-GC) device that can non-invasively and…

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